Water → 4-(3-Methoxy-4-methylphenoxy)aniline

HRID 1023519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1023519
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[O:18][CH3:19].O.[Cl-].[NH4+]>O1CCCC1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[O:18][CH3:19]

Komponenten

5

Edukt 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 672363822-Methoxy-1-methyl-4-(4-nitrophenoxy)benzene2×

Produkt 1

HCID 672355644-(3-Methoxy-4-methylphenoxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-2-(methyloxy)-4-[(4-nitrophenyl)oxy]benzene (Intermediate 19, 1.43 g) in tetrahydrofuran (65 mL)/water (32.5 mL) iron (1.540 g, 27.6 mmol) and then ammonium chloride (1.475 g, 27.6 mmol) were added and the reaction mixture was stirred for 5 hours at room temperature. The catalyst was filtered off and the solution was diluted with a saturated solution of Na2CO3 (10 mL) and extracted with ethyl acetate (2 times 60 mL). Combined organic layers were dried over sodium sulphate, filtered and evaporated to the title compound (1.25 g) as a brown/red solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. additionthe solution was diluted with a saturated solution of Na2CO3 (10 mL)
  3. extractionextracted with ethyl acetate (2 times 60 mL)
  4. dry with materialCombined organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated to the title compound (1.25 g) as a brown/red solid

Quellen und Nachweise

ORD-Eintrag
ord-62e267158f1b4f5fae3e775a4ec8147b
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722695B2

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