Methyl 3-{[(benzyloxy)carbonyl]amino}-1-methyl-1H-pyrazole-5-carboxylate → methyl 3-amino-1-methyl-1H-pyrazole-5-carboxylate

HRID 1024318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1024318
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH3:21])[N:7]=[C:8]([NH:10]C(OCC2C=CC=CC=2)=O)[CH:9]=1)=[O:4]>[Pd].CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH3:21])[N:7]=[C:8]([NH2:10])[CH:9]=1)=[O:4]

Komponenten

4

Edukt 1

HCID 14266058Methyl 3-{[(benzyloxy)carbonyl]amino}-1-methyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 13248993methyl 3-amino-1-methyl-1H-pyrazole-5-carboxylateAusbeute 101,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5-Benzyloxycarbonylamino-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (643, 2.2 g, 7.6 mmol) was combined with methanol (50 mL) and 10% palladium on carbon (500 mg). The mixture was stirred under an atmosphere of hydrogen for three hours. The mixture was filtered through Celite and the solvent was removed under reduced pressure to give the desired compound (644, 1.2 g, 98%). (ESI) [M+H+]+=156.1.

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2f0df251e1c040cfa5ba801d364d7f4c
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722702B2

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