Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole

HRID 1024349

Reaktionsgleichung

Reaktionsgleichung von HRID 1024349
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 858382-((Dimethylamino)methyl)cyclohexanone

Produkt 1

HCID 593393383,3a,4,5,6,7-hexahydro-2H-indazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel2×

Versuchsvorschrift

Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. temperaturethe mixture was slowly warmed
  3. temperaturerefluxed for 20 hours
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e0d9f0912948409299d9943f1d60f40e
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722887B2

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