3-Amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide → 3-Amino-N-ethyl-2-hydroxy-N-methoxybenzenesulfonamide

HRID 1024575Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1024575
[NH2:1][C:2]1[C:3]([OH:17])=[C:4]([S:9]([N:12]([O:15][CH3:16])[CH2:13][CH3:14])(=[O:11])=[O:10])[C:5](Cl)=[CH:6][CH:7]=1.[H][H]>CCO.[Pd]>[NH2:1][C:2]1[C:3]([OH:17])=[C:4]([S:9]([N:12]([CH2:13][CH3:14])[O:15][CH3:16])(=[O:10])=[O:11])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 866386363-Amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 866386403-Amino-N-ethyl-2-hydroxy-N-methoxybenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A dispersion of 10% Pd/C (200 mg) in a solution of 3-amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide (Int. FA step 2) (400 mg, 1.425 mmol) in EtOH (50 ml) was placed under a positive pressure of hydrogen at 0.5 bar above atmospheric pressure. After 5 hours, the catalyst was removed by filtration through Celite® (filter material), and the filtrate was reduced in vacuo. The resulting solid was used in the next step, without further purification.

Aufarbeitung

  1. customthe catalyst was removed by filtration through Celite® (filter material)
  2. customThe resulting solid was used in the next step, without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5ae95c72e6694c1f951c73782bc021f3
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722925B2

Notizen zur Reaktion

Wird geladen…