Ethanol → 4-Chloro-2-[[(2,3-difluorophenyl)methyl]thio)-6-ethoxy-pyrimidine

HRID 1024860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1024860
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1.[H-].[Na+].[CH2:21]([OH:23])[CH3:22]>O>[Cl:8][C:6]1[CH:7]=[C:2]([O:23][CH2:21][CH3:22])[N:3]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:5]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 24758Sodium hydrideHCID 859280374,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidine

Produkt 1

HCID 866198724-Chloro-2-[[(2,3-difluorophenyl)methyl]thio)-6-ethoxy-pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (0.50 g) in ethanol (5 mL) was added 60% sodium hydride (72 mg) and the reaction mixture was stirred at ambient temperature for 6 h. The mixture was diluted with H2O and extracted with EtOAc (×2). The combined organic layers were dried (MgSO4), filtered and evaporated to give the subtitle compound as a clear, colourless oil. Yield: 0.53 g

Aufarbeitung

  1. extractionextracted with EtOAc (×2)
  2. dry with materialThe combined organic layers were dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-0c0d9555685c4876a3a1bbc6af3003e0
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722883B2

Notizen zur Reaktion

Wird geladen…