cis-1,2,3,6-Tetrahydrophthalimide → 1H-Isoindole-1,3(2H)-dione, hexahydro-

HRID 1025539

Reaktionsgleichung

Reaktionsgleichung von HRID 1025539
[C:1]1(=[O:11])[C@@H:9]2[C@@H:4]([CH2:5][CH:6]=[CH:7][CH2:8]2)[C:3](=[O:10])[NH:2]1>CO.[Pd]>[C:1]1(=[O:11])[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[C:3](=[O:10])[NH:2]1

Komponenten

4

Edukt 1

HCID 92888cis-1,2,3,6-Tetrahydrophthalimide

Produkt 1

HCID 735591H-Isoindole-1,3(2H)-dione, hexahydro-Ausbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (3aR,7aS)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (3.0 g, 19.9 mmol) and 10% Pd/C (300 mg) in MeOH (100 mL) was shaken in an H2 atmosphere (300 psi) in a Parr apparatus for 24 h. The reaction mixture was filtrated and the liquids concentrated to dryness, affording the title compound (2.6 g, 16.99 mmol), that was sued without any further purification, as a white powder.

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe liquids concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-eebc4f521baf4b0f85da8ce609a1ac54
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08729098B2

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