Bromine → Ethyl 3-bromo-2-oxobutanoate

HRID 1028408

Reaktionsgleichung

Reaktionsgleichung von HRID 1028408
[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH2:6][CH3:7])[CH3:2].[Br:10]Br>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH:6]([Br:10])[CH3:7])[CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 85195ethyl acetoacetate, sodium salt

Produkt 1

HCID 11117285Ethyl 3-bromo-2-oxobutanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The 2-oxo-butyric acid ethyl ester prepared above was dissolved in chloroform (100 mL) and bromine (20.964 g, 131.19 mmol) was added dropwise at room temperature. The reaction mixture was allowed to stir for 18 h. Concentration of the reaction mixture under reduced pressure provided 12.0 g of the title compound as an orange oil. 1H NMR (CDCl3) δ 4.39 (q, 2H), 4.32 (q, 1H), 1.88 (d, 3H), 1.39 (t, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-a3102cce8b0343389afa889c1c18dcc1
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735588B2

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