Oxalyl chloride → 2-Bromo-3-methylbenzoyl chloride

HRID 1028940

Reaktionsgleichung

Reaktionsgleichung von HRID 1028940
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 27355882-Bromo-3-methylbenzoic acid

Produkt 1

HCID 141743752-Bromo-3-methylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A suspension of 2-bromo-3-methylbenzoic acid (2.07 g, 9.63 mmol) in DCM (48.1 mL) was cooled to 0° C. Oxalyl chloride (0.9 mL, 10.14 mmol) was added dropwise via syringe. After addition, the cooling bath was removed and the reaction mixture stirred overnight. The mixture was concentrated in vacuo to remove solvent and excess reagent, affording 2-bromo-3-methylbenzoyl chloride as a cloudy white oil.

Aufarbeitung

  1. additionAfter addition
  2. customthe cooling bath was removed
  3. concentrationThe mixture was concentrated in vacuo
  4. customto remove solvent and excess reagent

Quellen und Nachweise

ORD-Eintrag
ord-83032d37c54a46f5b993f92c72bb64b3
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735384B2

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