Oxalyl chloride → 2-Bromo-3-methylbenzoyl chloride
Reaktionsgleichung
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
A suspension of 2-bromo-3-methylbenzoic acid (2.07 g, 9.63 mmol) in DCM (48.1 mL) was cooled to 0° C. Oxalyl chloride (0.9 mL, 10.14 mmol) was added dropwise via syringe. After addition, the cooling bath was removed and the reaction mixture stirred overnight. The mixture was concentrated in vacuo to remove solvent and excess reagent, affording 2-bromo-3-methylbenzoyl chloride as a cloudy white oil.
Aufarbeitung
- additionAfter addition
- customthe cooling bath was removed
- concentrationThe mixture was concentrated in vacuo
- customto remove solvent and excess reagent
Quellen und Nachweise
- ORD-Eintrag
- ord-83032d37c54a46f5b993f92c72bb64b3
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08735384B2
Notizen zur Reaktion
Wird geladen…