HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → HCID 58168039, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Edukt | 1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid | HCID 21081527 | — |
| Edukt | 1-(4-Amino-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168367 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Lösungsmittel | Water ethylacetate | HCID 22728543 | — |
| Produkt | HCID 58168039 | HCID 58168039 | 62,3% |
Reaktionsschritte
Compound 137 (40 mg, 0.13 mmol), 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (37 mg, 0.16 mmol), BOP-Cl (50 mg, 0.20 mmol), and DIEA (0.07 mL, 0.40 mmol) were suspended in dioxane (2 mL), and stirred overnight at room temperature. The reaction mixture was diluted with EtOAc/H2O. The resulting precipitate was filtered, washed with EtOAc/H2O, and dried under vacuum to provide 181 (42 mg, 61% yield) as a white solid. LC-MS (M+H=519, obsd.=519).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08735584B2 |
| Quelldatensatz | uspto-grants-2014_05 |
| ORD ID | ord-3d52bb7c09c5435a8b31588ccdd7d5cf |
| Quellennotiz | uspto-grants-2014_05 |