Phenyl isocyanate → 7-(6-Oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid phenylamide

HRID 1029186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1029186
[O:1]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:21]=[CH:20][N:19]=[C:18]4[C:13]=3[C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16](=[O:22])[NH:17]4)[CH:9]=[CH:10][C:5]=2[NH:4][CH2:3][CH2:2]1.[N:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[C:28]=[O:29]>>[C:30]1([NH:27][C:28]([N:4]2[C:5]3[CH:10]=[CH:9][C:8]([O:11][C:12]4[CH:21]=[CH:20][N:19]=[C:18]5[C:13]=4[C:14]4[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=4[C:16](=[O:22])[NH:17]5)=[CH:7][C:6]=3[O:1][CH2:2][CH2:3]2)=[O:29])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Komponenten

3

Edukt 2

HCID 7672Phenyl isocyanateHCID 698108831-(3,4-Dihydro-2H-benzo[1,4]oxazin-7-yloxy)-5H-benzo[c][1,8]naphthyridin-6-one

Produkt 1

HCID 698118837-(6-Oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid phenylamideAusbeute 7,7 %

Versuchsvorschrift

The title compound was synthesized according to the procedure described for the preparation of Example 221 using 218 (50 mg, 0.14 mmol) and isocyanato benzene (26 mg, 0.22 mmol) to provide 223 (5 mg, 7% yield) as a tan solid. LC-MS (M+H=465, obsd.=465).

Aufarbeitung

  1. customThe title compound was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-677ac0db55e1431a9165c57b4369523c
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735584B2

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