Benzamide, N-(4-aminophenyl)- → N-[4-[(7-hydroxy-6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]benzamide

HRID 1029269

Reaktionsgleichung

Reaktionsgleichung von HRID 1029269
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:21][CH:20]=1>>[OH:17][C:13]1[C:5]2[C:6](=[O:12])[NH:7][C:8]3[C:3]([C:4]=2[CH:16]=[CH:15][CH:14]=1)=[C:2]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)[CH:11]=[CH:10][N:9]=3

Komponenten

3

Edukt 2

HCID 87196Benzamide, N-(4-aminophenyl)-HCID 68649040CID 68649040

Produkt 1

HCID 44205295N-[4-[(7-hydroxy-6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]benzamide

Versuchsvorschrift

The intermediate ethyl ester was synthesized according to the procedure described for the preparation of Example 378, method 2 using 1-chloro-7-hydroxy-5H-benzo[c][1,8]naphthyridin-6-one and N-(4-amino-phenyl)-benzamide to provide 446. LC-MS (M+H=423, obsd.=423). 1H NMR (400 MHz, DMSO-d6): δ, 6.95 (d, 2H), 7.21 (d, 2H), 7.55 (m, 2H), 7.76 (d, 2H), 7.95 (d, 2H), 8.09 (d, 1H), 8.21 (d, 1H), 8.88 (s, 1H), 10.23 (s, 1H).

Quellen und Nachweise

ORD-Eintrag
ord-6af81c906a194c6e9012ff7afc0ac752
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735584B2

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