HCID 19774261, Verbindung → N-(4-(2-Aminoethyl)phenyl)methanesulfonamide

HRID 1029744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1029744
C([NH:8][CH2:9][CH2:10][C:11]1[CH:21]=[CH:20][C:14]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:12]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][CH2:9][CH2:10][C:11]1[CH:21]=[CH:20][C:14]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:12]=1

Komponenten

4

Edukt 1

HCID 19774261HCID 19774261, Verbindung

Produkt 1

HCID 22018499N-(4-(2-Aminoethyl)phenyl)methanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4'-(2-Benzylaminoethyl)methanesulfonanilide (XXIX.HCl) (8.0 g) and 20% Pd/C (0.5 g) were combined in MeOH (200 ml) and heated at 40° for 18 hours in a Parr hydrogenator under an average hydrogen pressure of 3 atmospheres. The catalyst was filtered off. Concentration of the filtrate caused precipitation of Compound (XXVIII).HCl, 5.5 g as a white solid, m.p. 244°-246° (decomp.), whose elemental analysis for C, H, and N, and NMR spectrum were consistent with the structure indicated.

Aufarbeitung

  1. temperatureheated at 40° for 18 hours in a Parr hydrogenator under an average hydrogen pressure of 3 atmospheres
  2. filtrationThe catalyst was filtered off
  3. customprecipitation of Compound (XXVIII)

Quellen und Nachweise

ORD-Eintrag
ord-eba28b5ddc894996b5ee3f32548ff8a8
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05102914

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