Hydrochloric Acid → 4-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

HRID 1030472Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1030472
[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:9]2=[CH:13][N+:14]([O-:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].C([OH:21])C.Cl>O>[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:13](=[N:14][OH:16])[C:9]2=[O:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 30243963-Benzyl-2-nitromethylene-thiazolidine

Produkt 1

HCID 851863704-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2.36 g (0.01 mol) of 3-phenylmethyl-2-nitromethylenethiazolidine are boiled under reflux in the mixture of 50 ml of 1N sodium hydroxide solution and 25 ml of ethanol until the dissolution of the starting substance (when, based on the TLC examination, no starting substance is detected in a sample taken from the reaction mixture). Then, the mixture is cooled, acidified by adding hydrochloric acid diluted to 1:1 with water (to a pH value of 1), the precipitated product is filtered off, washed with water and dried to give the title compound in a yield of 2,15 g (91%), m.p.: 225°-227° C.

Aufarbeitung

  1. temperatureThen, the mixture is cooled
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-31ba42b11ab441dfbe9a2c3b3d10d5b8
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05106846

Notizen zur Reaktion

Wird geladen…