Hydrogen Peroxide → Ethyl 6-methyl-1-oxo-1lambda~5~-pyridine-3-carboxylate

HRID 1030510

Reaktionsgleichung

Reaktionsgleichung von HRID 1030510
[CH3:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[OH:13]O>C(O)(=O)C>[CH2:9]([O:8][C:6]([C:5]1[CH:11]=[CH:12][C:2]([CH3:1])=[N+:3]([O-:13])[CH:4]=1)=[O:7])[CH3:10]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 281994Ethyl 6-methylnicotinate

Produkt 1

HCID 15045502Ethyl 6-methyl-1-oxo-1lambda~5~-pyridine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 14.9 g of ethyl 6-methylnicotinate, 60 ml of acetic acid and 21.5 ml of 30% hydrogen peroxide was stirred at 80° C. for 16 hours, the reaction liquid was concentrated under a reduced pressure, water was added to the concentrate, and the mixture was extracted with chloroform. The chloroform layer was washed with an aqueous solution of potassium carbonate and dried over anhydrous potassium carbonate, and the solvent was removed under a reduced pressure to obtain 14.0 g of 5-ethoxycarbonyl-2-methyl pyridine-1-oxide. ##STR6##

Aufarbeitung

  1. customthe reaction liquid
  2. concentrationwas concentrated under a reduced pressure, water
  3. additionwas added to the concentrate
  4. extractionthe mixture was extracted with chloroform
  5. washThe chloroform layer was washed with an aqueous solution of potassium carbonate
  6. dry with materialdried over anhydrous potassium carbonate
  7. customthe solvent was removed under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ee29a6252c3b4ec497a0dca1f09e593b
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05106859

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