Reaktionsgleichung
O.NN.[F:4][C:5]1[CH:6]=[CH:7][C:8]([N+:23]([O-:25])=[O:24])=[C:9]([CH2:11][N:12]2C(=O)C3=CC=CC=C3C2=O)[CH:10]=1.Cl>C(O)C>[F:4][C:5]1[CH:6]=[CH:7][C:8]([N+:23]([O-:25])=[O:24])=[C:9]([CH:10]=1)[CH2:11][NH2:12]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
85% Hydrazine hydrate (1.67 ml) was added to a suspension of N-(5-fluoro-2-nitrophenyl)methyl-phthalimide (7.1 g) in ethanol (90 ml). The reaction mixture was heated to reflux for 3 hours, then cooled to 40° C. Hydrochloric acid was added and stirring was continued at that temperature for a further hour; then the solvent was removed under vacuum. The residue was taken up in water and the solid which separated was discarded. The mother liquors were treated with 10% sodium hydroxide and extracted with diethyl ether. After evaporation of the solvent 3.5 g of title compound were obtained as a reddish oil.
Aufarbeitung
- temperatureThe reaction mixture was heated
- temperatureto reflux for 3 hours
- waitwas continued at that temperature for a further hour
- customthen the solvent was removed under vacuum
- customthe solid which separated
- additionThe mother liquors were treated with 10% sodium hydroxide
- extractionextracted with diethyl ether
- customAfter evaporation of the solvent 3.5 g of title compound
- customwere obtained as a reddish oil
Quellen und Nachweise
- ORD-Eintrag
- ord-4c59c47191424f8a97e69a74222fba5b
- Quelldatensatz
- uspto-grants-1992_04
- Patentnummer
- US05106851
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