Triethylamine → HCID 178507339, Verbindung

HRID 1031110Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1031110
[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:8]3=[N:13]O[N:15]=[C:7]3[CH:6]=[CH:5][C:4]=2[N:3]=1.C(N(CC)CC)C>CN(C)C=O.[Pd]>[NH2:13][C:8]1[C:7]([NH2:15])=[CH:6][CH:5]=[C:4]2[C:9]=1[N:10]=[C:11]([OH:12])[C:2]([OH:1])=[N:3]2

Komponenten

5

Edukt 2

HCID 8471TriethylamineHCID 178517014HCID 178517014, Verbindung

Produkt 1

HCID 178507339HCID 178507339, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 5,0 g (24,5 mmol) 7,8-dihydroxy-1,2,5-oxadiazolo(3,4-f)quinoxaline and 6,8 ml (49 mmol) triethylamine in 500 ml dimethylformamide was hydrogenated at atm. pressure using 5% Pd-C (0,5 g) as a catalyst. The reaction mixture was filtered and evaporated in vacuo. The residue was stirred with water, and the precipitate was filtered off to give 4,5 g (96%) 5,6-diamino-2,3-dihydroxyquinoxaline, m.p. >300° C. NMR (DMSO-d6): 11.0 (2H, broad m), 6.43 (1H,d), 6.23 (1H,d), 4.5 (4H, broad m).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customevaporated in vacuo
  3. filtrationthe precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-a18d8b78bff6497e918c5bdc550f25fe
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05109001

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