Hydrochloric Acid → HCID 14839596, Verbindung

HRID 1031583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1031583
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([S:18][CH2:19][CH3:20])=[C:12]([F:17])[CH:13]=2)[N:8]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>O>[F:17][C:12]1[CH:13]=[C:14]2[C:9](=[N:10][C:11]=1[S:18][CH2:19][CH3:20])[N:8]([C:21]([CH3:23])([CH3:24])[CH3:22])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:15]2=[O:16]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14839595HCID 14839595, Verbindung

Produkt 1

HCID 14839596HCID 14839596, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of 0.23 g (0.65 mmoles) of 6-fluoro-7-ethylthio-(1,1-dimethylethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester in 1 mL of water was treated with 1.3 mL of 1N aqueous sodium hydroxide and the mixture was heated under reflux for 45 minutes. The resulting precipitate was acidified with 1 mL of 2N hydrochloric acid, filtered, washed with water and dried in vacuo at 50° C. to give 0.196 g of titled compound. MP 215° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 minutes
  3. filtrationfiltered
  4. washwashed with water
  5. customdried in vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-bf629bc3c9004a779d429a6eda39d1cb
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04954507

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