Imidazole → 3-[(1H-imidazol-1-yl)methyl]-1,2-benzisoxazole

HRID 1032327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032327
[H-].[Na+].O.[NH:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.Br[CH2:10][C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][N:12]=1>CCCCCC.CN(C)C=O>[N:4]1([CH2:10][C:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[O:13][N:12]=2)[CH:8]=[CH:7][N:6]=[CH:5]1

Komponenten

7

Edukt 4

HCID 795ImidazoleHCID 962WaterHCID 24758Sodium hydrideHCID 34991891,2-Benzisoxazole, 3-(bromomethyl)-

Produkt 1

HCID 145750023-[(1H-imidazol-1-yl)methyl]-1,2-benzisoxazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittel2×HCID 8058HexaneLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

Sodium hydride (50% in mineral oil, 3.4 g, 0.071 mole) is washed free of mineral oil with hexane (3×30 mL) and suspended in dimethylformamide (100 mL). This suspension is well stirred and maintained near room temperature (water bath) during the dropwise addition of a solution of imidazole (4.8 g, 0.071 mole) in dimethylformamide (25 mL). The reaction mixture is stirred at room temperature for 1 hour when 3-bromomethyl-1,2-benzisoxazole (15.0 g, 0.071 mole) is added all at once. The mixture is then heated at 85° C. for 8 hours. The solvent is evaporated in vacuo and the residue is taken up in methylene chloride (200 mL) and washed with water (3×50 mL). The organic solution is dried over anhydrous sodium sulfate, filtered and evaporated to give 3-[(1H-imidazol-1-yl)methyl]-1,2-benzisoxazole, which is purified by recrystallisation from isopropanol, m.p. 52-55° C. The free base is converted to the hydrochloride salt m.p. 145-146° C., when its solution in isopropanol is treated with a small excess of ethereal hydrogen chloride.

Aufarbeitung

  1. additionis added all at once
  2. customThe solvent is evaporated in vacuo
  3. washwashed with water (3×50 mL)
  4. dry with materialThe organic solution is dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-202d7386ca9c4d8ab7768b44b259af98
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04957931

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