Sodium Carbonate → Benzene, 1,1'-[(2-bromoethoxy)methylene]bis[4-fluoro-

HRID 1032338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032338
Br[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+].[Br:23][CH2:24][CH2:25][OH:26]>O>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[O:26][CH2:25][CH2:24][Br:23])=[CH:4][CH:5]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 108982-BromoethanolHCID 676651,1'-(Bromomethylene)bis(4-fluorobenzene)

Produkt 1

HCID 10568186Benzene, 1,1'-[(2-bromoethoxy)methylene]bis[4-fluoro-Ausbeute 73,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

A mixture of 49.5 g (0.175 mole) of bromo bis(4-fluoro phenyl)methane, 22.4 g (0.21 mole) of sodium carbonate and 26.9 g (0.21 mole) of 2-bromoethanol was stirred at 130° C. for 15 hours. After cooling, the reaction mixture was taken up with water and extracted with ether. The ethereal phase was washed, dried on sodium sulfate and then concentrated dry. Distillation of the residue yielded 41.9 g (yield: 69.4%) of 1-[bis(4-fluorophenyl) methoxy]-2-bromoethane.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. washThe ethereal phase was washed
  4. customdried on sodium sulfate
  5. concentrationconcentrated
  6. customdry
  7. distillationDistillation of the residue

Quellen und Nachweise

ORD-Eintrag
ord-cf0e627371b74d7bb7c0c58302ca1d8b
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04957927

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