Diisopropyl Ether → N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amine

HRID 1032523

Reaktionsgleichung

[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.C(O[CH:19](N(C)C)[N:20]([CH3:22])[CH3:21])(C)(C)C.C(OC(C)C)(C)C>>[CH3:19][N:20]([CH3:22])[CH:21]=[CH:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

Komponenten

Edukt 3

HCID 7914Diisopropyl Ether

HCID 79885tert-Butoxy bis(dimethylamino)methane

HCID 221660184-Methyl-7-nitro-1H-indazole

Produkt 1

HCID 54098844N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amineAusbeute 94,8 %

Versuchsvorschrift

17.7 g of 4-methyl-7-nitro-1H-indazole [Chem. Ber. 37: 2556 (1904)] and 68.0 g of tertbutoxybis(dimethylamino)methane are heated to 80° C. for 45 minutes, combined with diisopropyl ether, suctioned off, and washed with diisopropyl ether, thus producing 22.0 g of N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amine, mp 255° C.

Aufarbeitung

washwashed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag: ord-5fcae8f3132c4fecae897f527f925d0c
Quelldatensatz: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04958026

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