HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(7-nitro-1H-indazol-4-yl)acetonitrile → 2-(7-amino-1H-indazol-4-yl)acetonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(7-nitro-1H-indazol-4-yl)acetonitrile | HCID 13629308 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-(7-amino-1H-indazol-4-yl)acetonitrile | HCID 19354434 | 87,8% |
Reaktionsschritte
20.2 g of 2-(7-nitro-1H-indazol-4-yl)-acetonitrile in 750 ml of tetrahydrofuran is hydrogenated in the presence of 20.0 g of Raney nickel. The product is recrystallized from tetrahydrofuran/hexane, yielding 15.1 g of 2-(7-amino-1H-indazol-4-yl)acetonitrile, mp 164°-165° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04958026 |
| Quelldatensatz | uspto-grants-1990_09 |
| ORD ID | ord-eb4a0d8baa674734875fca2f76128da7 |
| Quellennotiz | uspto-grants-1990_09 |