3,6-Dichloro-2-nitrophenol → 2-amino-3,6-dichloroPhenol

HRID 1033031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1033031
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12]>C(O)C.C(O)(=O)C.[Pt]>[NH2:9][C:4]1[C:5]([Cl:8])=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[OH:12]

Komponenten

5

Edukt 1

HCID 30141723,6-Dichloro-2-nitrophenol

Produkt 1

HCID 103973432-amino-3,6-dichloroPhenolAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23939PlatinumKatalysatorHCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A yellow solution of 2,5-dichloro-6-nitrophenol (10.0 g, 48.0 mmol) in ethanol (200 mL) and acetic acid (13.8 mL) at 0° C. was catalytically reduced in the presence of 5% Platinum on charcoal (0.15 g) under an atmosphere of hydrogen (25 psi) for 1 hour in a Parr hydrogenator. The resultant colorless solution was filtered and concentrated under reduced pressure (15 torr). The residue was then dried under high vacuum (0.02 torr) overnight to yield 8.52 g (100%) of 2-amino-3,6-dichlorophenol.

Aufarbeitung

  1. filtrationThe resultant colorless solution was filtered
  2. concentrationconcentrated under reduced pressure (15 torr)
  3. customThe residue was then dried under high vacuum (0.02 torr) overnight

Quellen und Nachweise

ORD-Eintrag
ord-8ed0c95016094406819391c7adda635e
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05308854

Notizen zur Reaktion

Wird geladen…