Sodium Iodide → 3-Iodo-1-phenylpropan-1-ol
Reaktionsgleichung
Cl[CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5].[Na+].[I-:13]>CC(C)=O>[I:13][CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
(Compound 14) (10.1 g) was dissolved in acetone (200 ml) saturated with NaI. The mixture was refluxed for 12 h and subsequently stirred at RT for 3 days. The mixture was evaporated to dryness and the residue extracted with H2O/ether. The etheral layer separated and washed with H2O and saturated NaCl-solution. Resulting in 12.5 g of 3-iodo-1-phenyl-1-propanol (compound 15).
Aufarbeitung
- temperatureThe mixture was refluxed for 12 h
- customThe mixture was evaporated to dryness
- extractionthe residue extracted with H2O/ether
- customThe etheral layer separated
- washwashed with H2O and saturated NaCl-solution
Quellen und Nachweise
- ORD-Eintrag
- ord-6155afab3dc444328dd314a10aa65438
- Quelldatensatz
- uspto-grants-1994_05
- Patentnummer
- US05310756
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