Diethyl Ether → 2-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

HRID 1033748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1033748
[CH2:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH2:3][N:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].C[I:16].[CH2:17](OCC)C>C(#N)C>[I-:16].[CH2:13]([O:12][C:10]([NH+:2]1[CH2:1][C:9]2[CH:8]=[CH:7][N:6]([CH3:17])[CH2:5][C:4]=2[CH2:3]1)=[O:11])[CH3:14]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 18953633ethyl 1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

Produkt 1

HCID 678240962-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

9.6 g (50 mmol) of ethyl 2,3-dihydro-1H-pyrrolo-[3,4-c]pyridine-2-carboxylate and 6.3 ml (100 mmol) of methyl iodide are refluxed for 15 hours in 50 ml of acetonitrile. The batch is poured into diethyl ether, and the salt which has precipitated is filtered off with suction and dried in the air.

Aufarbeitung

  1. customthe salt which has precipitated
  2. filtrationis filtered off with suction
  3. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-59124bde501248bdb147f9bb83755fba
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05312823

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