[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester → [1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

HRID 10346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10346
[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:16][CH2:15]2)[CH2:13][N:12](CC2C=CC=CC=2)[CH2:11]1)[CH3:9])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:15][CH2:16]2)[CH2:13][NH:12][CH2:11]1)[CH3:9])([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 21041206[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 21041207[1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of [1-(5-benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester (Example A4a, 1.47 g) in methanol (30 mL) in a Parr shaker is treated with 10% palladium on carbon (0.5 g) and hydrogen introduced (50 psi) for 24 hours. The reaction mixture is filtered through celite, washed with methanol, and the combined filtrate concentrated in vacuo to afford the title compound. MS CI: m/z 241 (MH+).

Aufarbeitung

  1. additionintroduced (50 psi) for 24 hours
  2. filtrationThe reaction mixture is filtered through celite
  3. washwashed with methanol
  4. concentrationthe combined filtrate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c97a1145efa84e81865b68656041089c
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094780B1

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