Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate → Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate

HRID 1034651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1034651
C([N:8]1[CH2:13][CH2:12][C@@H:11]([CH:14]2[CH2:16][CH2:15]2)[C@H:10]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:20]([O:19][C:18](=[O:24])[NH:17][C@H:10]1[C@H:11]([CH:14]2[CH2:15][CH2:16]2)[CH2:12][CH2:13][NH:8][CH2:9]1)([CH3:23])([CH3:21])[CH3:22]

Komponenten

5

Edukt 2

HCID 67045345Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 86652140Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate (1.20 g, 3.63 mmol) and 10% Pd/C (0.39 g, 0.36 mmol) in methanol (20 mL) was charged with 1 atmosphere hydrogen and stirred at room temperature for 18 hours. The catalyst was removed by filtration and washed with methanol (20 mL). The filtrate was concentrated in vacuo to give tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate (0.87 g, 100%) as a solid.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol (20 mL)
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-42300988fe8e45d783a9e5ae5f1c3ff5
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08545897B2

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