Hydrochloride methanol → cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

HRID 1035303Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1035303
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]2[CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][C@H:5]2[CH2:4][NH:3]1.Cl.CO>C(OCC)C>[CH2:13]1[C@H:6]2[C@H:5]([CH2:4][NH:3][C:2](=[O:1])[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=32)[CH2:16][NH:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 67249978Tert-butyl cis-7-oxo-1,2,4,4a,5,6,7,11b-octahydro-3h-pyrido[3,4-d][2]benzazepine-3-carboxylate

Produkt 1

HCID 49763200cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a suspension of Example 180G in 400 mL of diethyl ether was added 80 mL of HCl/methanol (5/V) at 25° C. The mixture was stirred overnight. The solid formed was collected and dried to obtain the title compound as the hydrochloride salt.

Aufarbeitung

  1. customThe solid formed
  2. customwas collected
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5286a10581514c068c51fe5b348b28b2
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546377B2

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