Water → (2,3,4,5-tetrahydro-1H-1-benzazepin-2-yl)methanamine

HRID 1035309Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1035309
[N+:1](/[CH:4]=[C:5]1\[NH:6][C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[CH2:9][CH2:10][CH2:11]\1)([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[NH:6]1[C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[CH2:9][CH2:10][CH2:11][CH:5]1[CH2:4][NH2:1]

Komponenten

5

Edukt 3

HCID 962WaterHCID 13842538(2z)-2-(Nitromethylene)-2,3,4,5-tetrahydro-1h-1-benzazepineHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 13842540(2,3,4,5-tetrahydro-1H-1-benzazepin-2-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of Example 182D (0.643 g, 3.15 mmol) in tetrahydrofuran (31.5 mL) under argon was added dropwise lithium aluminum hydride in tetrahydrofuran (9.45 mL, 18.89 mmol), and the mixture was stirred at room temperature for 30 minutes. Water was added carefully and the mixture was extracted once with dichloromethane. The organic extract was dried over Na2SO4, and the solvent was evaporated to obtain the crude title compound which was used was used without purification for the next reaction. MS (ESI+) m/z 177.3 (M+H)+.

Aufarbeitung

  1. extractionthe mixture was extracted once with dichloromethane
  2. extractionThe organic extract
  3. dry with materialwas dried over Na2SO4
  4. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bf9c9902712b468197a4d7c765d4957c
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546377B2

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