5-nitro-6-((tetrahydro-2H-pyran-4-yl)methylamino)pyridine-3-sulfonamide → 5-Amino-6-((tetrahydro-2h-pyran-4-yl)methylamino)pyridine-3-sulfonamide

HRID 1036062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036062
[N+:1]([C:4]1[CH:5]=[C:6]([S:18]([NH2:21])(=[O:20])=[O:19])[CH:7]=[N:8][C:9]=1[NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([S:18]([NH2:21])(=[O:20])=[O:19])[CH:7]=[N:8][C:9]=1[NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Komponenten

5

Edukt 2

HCID 671268595-nitro-6-((tetrahydro-2H-pyran-4-yl)methylamino)pyridine-3-sulfonamideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 671265755-Amino-6-((tetrahydro-2h-pyran-4-yl)methylamino)pyridine-3-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of EXAMPLE 364E (0.16 g) and 5% palladium on carbon (0.025 g) in ethanol (5 mL) was treated with a balloon of hydrogen. The reaction mixture was stirred overnight. The solid was filtered off. The filtrate was concentrated. The residue was purified by flash chromatography on silica gel to give the title compound.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. concentrationThe filtrate was concentrated
  3. customThe residue was purified by flash chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-5272401d7ec74e0d81dbd595179b962e
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546399B2

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