Hydrochloric Acid → 6-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

HRID 1037128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1037128
[OH:1][B:2]1[C:6]2[CH:7]=[C:8]([CH:11]([NH:13]C(=O)OC(C)(C)C)[CH3:12])[CH:9]=[CH:10][C:5]=2[C:4]([CH3:22])([CH3:21])[O:3]1.[ClH:23].O>CO>[ClH:23].[NH2:13][CH:11]([C:8]1[CH:9]=[CH:10][C:5]2[C:4]([CH3:21])([CH3:22])[O:3][B:2]([OH:1])[C:6]=2[CH:7]=1)[CH3:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86685492Tert-butyl 1-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)ethylcarbamate

Produkt 1

HCID 866854936-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 1-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)ethyl-carbamate (0.93 mmol) in MeOH (10 mL) was added 6N HCl (10 mL). The mixture was stirred at rt overnight. The mixture was poured into water and washed with EA (50 mL×2). The water layer was lyophilized to give crude 6-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride. It was used in the next step without further purification.

Aufarbeitung

  1. washwashed with EA (50 mL×2)

Quellen und Nachweise

ORD-Eintrag
ord-ebeb44aa01924eb0a1be282b20d850da
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546357B2

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