Water → HCID 68735775, Verbindung

HRID 1037510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1037510
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][C:10]([I:15])=[CH:9][CH:8]=3.Br[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][OH:28].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[I:15][C:10]1[CH:9]=[CH:8][C:7]2[N:6]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][OH:28])[C:5]3[C:13]([C:12]=2[CH:11]=1)=[CH:14][C:2]([I:1])=[CH:3][CH:4]=3

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 7416311-Bromo-1-undecanolHCID 31164883,6-Diiodo-9H-carbazole

Produkt 1

HCID 68735775HCID 68735775, VerbindungAusbeute 88,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 3,6-diiodocarbazole (10.0 g, 23.87 mmol) and 11-bromo-1-undecanol (7.0 g, 27.87 mmol) in DMF (100.0 ml) was added K2CO3 (32.0 g, 231.33 mmol). The reaction was carried out at room temperature for 24 h. Water (300 ml) was added. The precipitate was filtered. The crude product was purified by silica gel column using Hexane/ethyl acetate (7:3) as solvent. 12.4 g (87.9%) of pure product as white solid was obtained.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. customThe crude product was purified by silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-369d79617fab4335ab4e775fad1257f2
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546505B2

Notizen zur Reaktion

Wird geladen…