Methanol → HCID 59579790, Verbindung

HRID 1037786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1037786
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14])([O-])=O.CO>[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 595797305-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one

Produkt 1

HCID 59579790HCID 59579790, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Into a round bottom flask was combined 5-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one (0.85 g, 0.0029 mol), Palladium/C (0.05 g, 0.0005 mol) and methanol (200 mL, 5 mol). The reaction mixture was stirred under hydrogen balloon at room temperature for 40 mins. The mixture was filtered over celite, MeOH was removed and the solid was yield (0.54 mg). MS m/z=266.0 (M+1). 1H NMR (DMSO) δ 8.55 (d, J=4.8 Hz, 1 H), 7.77 (td, J=7.7, 1.8 Hz, 1 H); 7.44 (d, J=7.8 Hz, 1 H), 7.35-7.25 (m, 3 H), 7.17 (t, J=7.8 Hz, 1 H), 6.95-6.85 (m, 1 H), 6.78 (d, J=7.8 Hz, 1 H), 6.28 (q, J=7.2 Hz, 1 H), 5.66 (s, 2 H), 1.75 (d, J=7.2 Hz, 3 H).

Aufarbeitung

  1. customInto a round bottom flask was combined
  2. filtrationThe mixture was filtered over celite, MeOH
  3. customwas removed
  4. customthe solid was yield (0.54 mg)

Quellen und Nachweise

ORD-Eintrag
ord-315a62beed394b28a6a13ca24c75e09b
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546579B2

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