N-methyl-5-nitro-1H-indazole-3-carboxamide → 5-Amino-N-methyl-1H-indazole-3-carboxamide

HRID 1038001

Reaktionsgleichung

Reaktionsgleichung von HRID 1038001
[CH3:1][NH:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[NH:7][N:6]=1)=[O:4]>CO.[Pd]>[CH3:1][NH:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[NH:7][N:6]=1)=[O:4]

Komponenten

4

Edukt 1

HCID 45810073N-methyl-5-nitro-1H-indazole-3-carboxamide

Produkt 1

HCID 225673195-Amino-N-methyl-1H-indazole-3-carboxamideAusbeute 105,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of compound 55 (65 mg) in 5 mL of methanol was added catalytic amount of 5% palladium on carbon. The mixture was stirred under a hydrogen atmosphere at room temperature for 4 hrs and filtered through celite. The filtrate was concentrated to afford compound 56 (59 mg).

Aufarbeitung

  1. filtrationfiltered through celite
  2. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-d15d4a00c4544cf7bcc3ef3ffa5f292f
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546404B2

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