Trifluoroacetic acid → HCID 58884968, Verbindung

HRID 1038071Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1038071
[CH3:1][O:2][C:3](=[O:10])[C:4]([C:6]([F:9])([F:8])[F:7])=[CH2:5].O([CH2:13][N:14]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:15][Si](C)(C)C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]([C:4]1([C:6]([F:9])([F:8])[F:7])[CH2:5][CH2:13][N:14]([CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:15]1)=[O:10]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 2782391Methyl 2-(trifluoromethyl)acrylate

Produkt 1

HCID 58884968HCID 58884968, VerbindungAusbeute 76,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred cold solution (0° C.) of 2-trifluoromethyl-acrylic acid methyl ester (308 mg, 2 mmol) and N-(methoxylmethyl)-N-(trimethylsilylmethyl)benzylamine (529 μl, 4.8 mmol) in dichloromethane (3 ml) was added slowly trifluoroacetic acid (31 μl). The resulting solution was allowed to stir at rt overnight and directly purified by column chromatography eluting with ethyl acetate in hexane (1:4) to provide 1-benzyl-3-trifluoromethyl-pyrrolidine-3-carboxylic acid methyl ester as oil (438 mg, 76%).

Aufarbeitung

  1. customdirectly purified by column chromatography
  2. washeluting with ethyl acetate in hexane (1:4)

Quellen und Nachweise

ORD-Eintrag
ord-0416ea96d91c447dac657ae4c9f0f925
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546404B2

Notizen zur Reaktion

Wird geladen…