Water → 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

HRID 1039061

Reaktionsgleichung

Reaktionsgleichung von HRID 1039061
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

Komponenten

6

Edukt 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 10796Cesium carbonateHCID 952642-Fluoro-5-nitropyridine

Produkt 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-fluoro-5-nitropyridine (0.5 g, 3.38 mmol), 1,2,4-triazole (0.22 g, 3.22 mmol) were added in DMF (6.4 mL), then cesium carbonate (3.14 g, 9.65 mmol) was added. The reaction was run at room temperature for 30 minutes. Water (50 mL) was added and product fell out of the solution. The solution was filtered and the solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL) to give the title compound as a white solid.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. washthe solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL)

Quellen und Nachweise

ORD-Eintrag
ord-f57ebb80bb79433bb24a6b091ca610d5
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552022B2

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