Sodium Hydroxide → 5-[5-(5-Chloro-2-hydroxy-phenyl)-isoxazol-3-yl]-pentanoic acid disodium salt
Reaktionsgleichung
[OH-].[Na+:2].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([OH:22])=[C:8]([C:10]2[O:14][N:13]=[C:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:11]=2)[CH:9]=1>O>[Na+:2].[Na+:2].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([OH:22])=[C:8]([C:10]2[O:14][N:13]=[C:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20])[CH:11]=2)[CH:9]=1.[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([OH:22])=[C:8]([C:10]2[O:14][N:13]=[C:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20])[CH:11]=2)[CH:9]=1Komponenten
4
Versuchsvorschrift
Add a solution of NaOH (739 mg, 18.5 mmol) in water (3 mL) to a suspension of 5-[5-(5-chloro-2-hydroxy-phenyl)-isoxazol-3-yl]-pentanoic acid (2.73 g, 9.23 mmol) in water (5 mL) and stir at room temperature. Heat to 55° C. for 1 hour, filter hot solution, concentrate, place in 50-60° C. vacuum oven for 2 days. Scrape and crush solids, place in 50-60° C. vacuum oven overnight to afford the title compound (3.14 g, 100%). MS (IS) 296 (M+1)+.