Formic Acid → 7-Methyl-4(3H)-quinazolinone

HRID 1042253

Reaktionsgleichung

Reaktionsgleichung von HRID 1042253
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:12](O)=O>>[CH3:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:6][CH:12]=[N:1]2)=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 28014742-Amino-4-methylbenzamide

Produkt 1

HCID 1354525337-Methyl-4(3H)-quinazolinoneAusbeute 84,5 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2-amino-4-methylbenzamide (20 g, 133 mmol) and formic acid (120 ml, 3129 mmol) was heated to 100° C. for 6 h. The reaction was cooled to RT and the volatiles were removed under reduced pressure. The residue was then washed carefully with aqueous saturated sodium bicarbonate and then with water. The tan solid was then dried in a vacuum oven at 45° C. overnight to give 7-methylquinazolin-4(3H)-one (18.00 g, 84% yield). MS (ESI, pos. ion) m/z: 161 [M+H]+

Aufarbeitung

  1. temperatureThe reaction was cooled to RT
  2. customthe volatiles were removed under reduced pressure
  3. washThe residue was then washed carefully with aqueous saturated sodium bicarbonate
  4. customThe tan solid was then dried in a vacuum oven at 45° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-60582e02612445eba4e8741687084f5f
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08557830B2

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