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Sodium Carbonate → 2-t-Butyldimethylsilyl-3-(t-butyldimethylsilyloxymethylene)-6-methoxy-7-isopropoxybenzofuran

HRID 1042589
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1042589
[CH:1]([O:4][C:5]1[C:10]([O:11][CH3:12])=[CH:9][C:8](I)=[CH:7][C:6]=1[OH:14])([CH3:3])[CH3:2].[Si:15]([C:22]#[C:23][CH2:24][O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16].[Cl-].[Li+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Si:15]([CH:22]1[C:23](=[CH:24][O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:27])[CH3:28])[C:7]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:5]([O:4][CH:1]([CH3:2])[CH3:3])[C:6]=2[O:14]1)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 10340Sodium CarbonateHCID 433294Lithium ChlorideHCID 10968062Tert-butyl(3-(tert-butyldimethylsilyl)prop-2-ynyloxy)-dimethylsilaneHCID 57421943HCID 57421943, Verbindung

Produkt 1

HCID 670422652-t-Butyldimethylsilyl-3-(t-butyldimethylsilyloxymethylene)-6-methoxy-7-isopropoxybenzofuran

Reagenzien, Katalysatoren, Lösungsmittel

2
HCID 167845palladium(II) acetateKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A suspension of 2-isopropoxy-3-methoxy-5-iodophenol (4.41 mmol), 1-(tert-butyl-dimethylsilanyl)-3-(tert-butyl-dimethyl-silanyloxy)-propyne (1.5 g, 5.28 mmol), lithium chloride (189 mg, 4.45 mmol) and sodium carbonate (2.34 g, 22.08 mmol) in dry dimethylformamide (5 mL) at 100° C. was deoxygenated 4 times by evacuation and backfilling with nitrogen. Palladium acetate (135 mg, 0.60 mmol) was added and the reaction vessel was degassed twice with nitrogen. The reaction mixture was then stirred at this temperature for 4 hours (tlc) and the solvent was removed by distillation under vacuum. The residue was dissolved in ethyl acetate (75 mL), stirred well, filtered and treated with triethylamine (5 mL). The solution was concentrated onto silica gel (10 g) and purified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%) to afforded the title compound a yellow oil; (1.45 g, 96%); 1H NMR (300 MHz, CDCl3) δ 7.24 (d, 1H, J=8.45 Hz), 6.88 (d, 1H, J=8.47 Hz), 4.80 (s, 2H, CH2), 4.73 (m, 1H), 3.88 (s, 3H, OMe), 1.36 (d, 6H, J=6.17 Hz), 0.94 (s, 9H), 0.92 (s, 9H), 0.35 (s, 6H), 0.12 (s, 6H).

Aufarbeitung

  1. customwas deoxygenated 4 times by evacuation and backfilling with nitrogen
  2. customthe reaction vessel was degassed twice with nitrogen
  3. customthe solvent was removed by distillation under vacuum
  4. dissolutionThe residue was dissolved in ethyl acetate (75 mL)
  5. stirringstirred well
  6. filtrationfiltered
  7. additiontreated with triethylamine (5 mL)
  8. concentrationThe solution was concentrated onto silica gel (10 g)
  9. custompurified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%)

Quellen und Nachweise

ORD-Eintrag
ord-88f0dfe4e9304f28b17f423269eb6ade
Quelldatensatz
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08557982B2

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