Trifluoroacetic acid → (3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate

HRID 10426

Reaktionsgleichung

Reaktionsgleichung von HRID 10426
[C:1]([C@@H:3]1[CH2:10][CH2:9][C@@H:8]2[N:4]1[C:5](=[O:19])[C@H:6]([NH:11]C(=O)OC(C)(C)C)[CH2:7]2)#[N:2].C1(SC)C=CC=CC=1.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH2:11][C@@H:6]1[CH2:7][C@H:8]2[N:4]([C@H:3]([C:1]#[N:2])[CH2:10][CH2:9]2)[C:5]1=[O:19]

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 91321587Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

Produkt 1

HCID 11357934(3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate

Versuchsvorschrift

80 mg of tert-butyl ((2R,5S,7aS)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate were C reacted with 10% thioanisole in 1 ml of trifluoroacetic acid for 30 min. The solvents were then removed in vacuo, and the residue was stirred with diusopropyl ether.

Aufarbeitung

  1. customThe solvents were then removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-300496268f1a4ca7a2622d242dab1799
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094800B2

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