Nitric Acid → HCID 178434743, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:17])=[CH:12][CH:13]=[N:14]3)=[CH:9][CH:8]=2)=[C:5]([CH3:18])[O:4][N:3]=1.[N+:19]([O-])([OH:21])=[O:20]>C(O)(=O)CC>[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:17])=[C:12]([N+:19]([O-:21])=[O:20])[CH:13]=[N:14]3)=[CH:9][CH:8]=2)=[C:5]([CH3:18])[O:4][N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 125 °C
Versuchsvorschrift
To a solution of 7-(3,5-dimethyl-4-isoxazolyl)-4-quinolinol (for a preparation see Intermediate 11, 8.5 g, 35 mmol) in propanoic acid (442 ml) was added nitric acid (7 ml) at room temperature, followed by heating the reaction mixture to 125° C. for 2 h. After cooling, the mixture was filtered, washed with isopropyl ether to give the title compound as a yellow solid (7.5 g, 75%). [APCI-MS] m/z: 283 [M−H]−, Rt 2.41 min.