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Sodium Bicarbonate → N-(2,2-Diphenylethyl)-2-(methylsulphonyl)-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine

HRID 10437
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 10437
O[O:2][S:3]([O-:5])=O.[K+].[C:7]1([CH:13]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:14][NH:15][C:16]2[N:24]=[C:23](SC)[N:22]=[C:21]3[C:17]=2[N:18]=[CH:19][N:20]3[CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][O:28]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:39](=O)([O-])O.[Na+]>O.CC(C)=O>[C:33]1([CH:13]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:14][NH:15][C:16]2[N:24]=[C:23]([S:3]([CH3:39])(=[O:5])=[O:2])[N:22]=[C:21]3[C:17]=2[N:18]=[CH:19][N:20]3[CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][O:28]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1
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Komponenten

6

Edukt 3

HCID 516892Sodium BicarbonateHCID 21978277N-(2,2-diphenylethyl)-2-(methylsulphanyl)-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amineHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 21978255N-(2,2-Diphenylethyl)-2-(methylsulphonyl)-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amineAusbeute 75,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180
Acetone
Lösungsmittel
HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of Oxone (trade mark) (potassium peroxymonosulphate) (44 g, 71.7 mmol) in water (200 ml) was added dropwise over 2 hours to a solution of N-(2,2-diphenylethyl)-2-(methylsulfanyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (Preparation 3) (25 g, 56.2 mmol) and sodium hydrogencarbonate (20 g, 238 mmol) in acetone (1000 ml) and water (250 ml). The resultant mixture was stirred at room temperature for 24 hours, filtered and the residue washed with acetone. The acetone was removed from the filtrate under reduced pressure and the resulting aqueous residue extracted with ethyl acetate and then dichloromethane. The combined organic layers were washed with brine, dried with anhydrous magnesium sulphate, filtered and the solvent removed under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane and then dried to afford the title compound as a white solid (20.32 g).

Aufarbeitung

  1. filtrationfiltered
  2. washthe residue washed with acetone
  3. customThe acetone was removed from the filtrate under reduced pressure
  4. extractionthe resulting aqueous residue extracted with ethyl acetate
  5. washThe combined organic layers were washed with brine
  6. dry with materialdried with anhydrous magnesium sulphate
  7. filtrationfiltered
  8. customthe solvent removed under reduced pressure
  9. customThe residue was triturated with diethyl ether
  10. filtrationfiltered
  11. washwashed with diethyl ether and pentane
  12. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c6bbeb5096df4e269e3f46d31c8cd773
Quelldatensatz
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07094769B2

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