Tetrabutylammonium Fluoride → HCID 86686338, Verbindung

Reaktionsgleichung

[Br:1][C:2]1[C:3]([CH2:10]Br)=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8].CCCC[N+](CCCC)(CCCC)CCCC.[F-:29]>>[Br:1][C:2]1[C:3]([CH2:10][F:29])=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8]

Komponenten

Edukt 2

HCID 2724141Tetrabutylammonium Fluoride

HCID 86686337HCID 86686337, Verbindung

Produkt 1

HCID 86686338HCID 86686338, Verbindung

Versuchsvorschrift

A mixture of 3-bromo-2-(bromomethyl)-4,6-dimethylpyridine (1.00 g) and TBAF (17.9 mL, 1 M solution in THF) was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 30%) to give the title compound (651 mg).

Aufarbeitung

concentrationThe reaction mixture was concentrated under reduced pressure
customthe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 30%)

Quellen und Nachweise

ORD-Eintrag: ord-641ade8db95e44018bf6e263c49f7f37
Quelldatensatz: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08563565B2

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