Methanol → HCID 178477595, Verbindung

HRID 1044387

Reaktionsgleichung

Reaktionsgleichung von HRID 1044387
[O:1]=[C:2]1[C@@:6]2([CH2:11][CH2:10][CH2:9][N:8](C(OCC3C=CC=CC=3)=O)[CH2:7]2)[CH2:5][CH2:4][N:3]1[C@H:22]1[CH2:27][CH2:26][C@H:25]([O:28][Si:29]([CH2:34][CH3:35])([CH2:32][CH3:33])[CH2:30][CH3:31])[CH2:24][CH2:23]1.CO>[Pd]>[CH2:32]([Si:29]([CH2:30][CH3:31])([CH2:34][CH3:35])[O:28][C@H:25]1[CH2:26][CH2:27][C@H:22]([N:3]2[CH2:4][CH2:5][C@:6]3([CH2:11][CH2:10][CH2:9][NH:8][CH2:7]3)[C:2]2=[O:1])[CH2:23][CH2:24]1)[CH3:33]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 178477596HCID 178477596, Verbindung

Produkt 1

HCID 178477595HCID 178477595, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

To a solution of benzyl (5S)-1-oxo-2-{trans-4-[(triethylsilyl)oxy]cyclohexyl}-2,7-diazaspiro[4.5]decane-7-carboxylate (2.4 g, 0.0048 mol) in methanol (10 mL, 0.2 mol) was added Pd/C, and the suspension was stirred at rt under a H2 balloon for 1.5 h. The inorganics were filtered and the filtrate was concentrated to afford the desired product.

Aufarbeitung

  1. filtrationThe inorganics were filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-da8bca61678646aeb0250b4a9ab7955f
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563570B2

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