2-Methyl-2-(3-nitropropyl)-1,3-dioxolane → 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

HRID 1044733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1044733
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][N+:10]([O-])=O)[O:6][CH2:5][CH2:4][O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][NH2:10])[O:6][CH2:5][CH2:4][O:3]1

Komponenten

4

Edukt 1

HCID 6383462-Methyl-2-(3-nitropropyl)-1,3-dioxolane

Produkt 1

HCID 5600073-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar, a mixture of 2-methyl-2-(3-nitro-propyl)-[1,3]dioxolane (1.80 g, 10.27 mmol) and Pd/C 10% (176 mg) in dry MeOH (35 mL) was stirred at rt under atmospheric H2 for 11 h. The reaction mixture was then filtered and concentrated under reduced pressure to give the title compound as a colorless oil. LC-MS-conditions 02: tR=0.25 min; [M+H]+=146.41.

Aufarbeitung

  1. customIn a flame dried round-bottomed flask equipped with a magnetic stir bar
  2. filtrationThe reaction mixture was then filtered
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2f1e704c1227438da0f54ac674e12714
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563714B2

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