Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 1044778

Reaktionsgleichung

Reaktionsgleichung von HRID 1044778
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>CC#N.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

Produkt 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (2.19 g, 12.31 mmol) in CH3CN (122 mL) was treated at rt with MnO2 (5.94 g, 61.52 mmol). The reaction mixture was stirred at rt until completion of the reaction, and then filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-79154917368b43f5baddd6744e4b48ad
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563714B2

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