Hydroxyacetonitrile → [Cyclopentyl(isopropyl)amino]acetonitrile
Reaktionsgleichung
O[CH2:2][C:3]#[N:4].[CH:5]([NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:7])[CH3:6]>O.C(O)C>[CH:9]1([N:8]([CH2:2][C:3]#[N:4])[CH:5]([CH3:7])[CH3:6])[CH2:13][CH2:12][CH2:11][CH2:10]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Hydroxyacetonitrile (8.2 ml of a 70% w/w solution in water, 0.1 mol) was added to a solution of N-isopropylcyclopentanamine (11.43 g, 0.09 mol) (Preparation 23) in ethanol (60 ml). The reaction mixture was heated under reflux for 3 hours, allowed to cool and the solvent removed under reduced pressure. The residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume) to give the title compound (14.1 g) as a clear oil.
Aufarbeitung
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 3 hours
- temperatureto cool
- customthe solvent removed under reduced pressure
- customThe residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume)
Quellen und Nachweise
- ORD-Eintrag
- ord-2edc0f68f55d4d2e9a504b31994f60af
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07094769B2
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