Sodium Bisulfite → 7-Fluoro-2,3-dihydro-1h-indol-2-one

HRID 1045039

Reaktionsgleichung

Reaktionsgleichung von HRID 1045039
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH:7]2SC.S(=O)(O)[O-].[Na+]>O>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2

Komponenten

4

Edukt 2

HCID 23665763Sodium BisulfiteHCID 569635307-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 37343717-Fluoro-2,3-dihydro-1h-indol-2-oneAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one (270.5 g) was dissolved in water (2000 g) and admixed with sodium bisulfite (300 g). The mixture was heated to reflux, in the course of which it was vigorously stirred. After 2.25 h, the mixture was cooled to 25° C. and isolated by filtration on a suction filter. It was washed twice with water (500 g each time) and then dried under reduced pressure (<50 mbar, 50° C.). This gave 7-fluoro-1,3-dihydro-2H-indol-2-one as a white solid (206.3 g, 95.1% by weight, 95% yield).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux, in the course of which it
  3. customisolated by filtration on a suction
  4. filtrationfilter
  5. washIt was washed twice with water (500 g each time)
  6. customdried under reduced pressure (<50 mbar, 50° C.)

Quellen und Nachweise

ORD-Eintrag
ord-55c6420b1cdb4957ae254223264664a4
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563749B2

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