Diisopropyl Ether → 3-[N'-(acetyloxy)carbamimidoyl]phenyl acetate

HRID 1045371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1045371
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[CH:6]=1)[NH2:4].C(N(CC)CC)C.[C:19](OC(=O)C)(=[O:21])[CH3:20].[CH:26]([O:29]C(C)C)(C)[CH3:27]>C(Cl)Cl>[C:19]([O:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([C:3](=[N:2][O:1][C:26](=[O:29])[CH3:27])[NH2:4])[CH:6]=1)(=[O:21])[CH3:20]

Komponenten

6

Edukt 4

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 54381771N,3-dihydroxybenzenecarboximidamide

Produkt 1

HCID 866633073-[N'-(acetyloxy)carbamimidoyl]phenyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 10.2 g (67 mmol) of the product obtained in Step A above in 150 ml of CH2Cl2 there are added 28 ml (0.201 mol) of triethylamine. 13.9 ml (0.147 mol) of acetic anhydride are added dropwise and the solution is stirred overnight at ambient temperature. After washing 3 times with water and then with brine, the organic phase is dried over MgSO4 and evaporated. The solid obtained is taken up in isopropyl ether and then filtered and dried to yield the title compound.

Aufarbeitung

  1. washAfter washing 3 times with water
  2. dry with materialwith brine, the organic phase is dried over MgSO4
  3. customevaporated
  4. customThe solid obtained
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-df65c7fb2edb43108c94209531d66d1d
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569285B2

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