Acetic Anhydride → N'-(acetyloxy)-4-iodobenzenecarboximidamide

HRID 1045377Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1045377
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4].C(N(CC)CC)C.[C:19](OC(=O)C)(=[O:21])[CH3:20]>C(Cl)Cl.C(OC(C)C)(C)C>[C:19]([O:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4])(=[O:21])[CH3:20]

Komponenten

6

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 4429393N-Hydroxy-4-iodo-benzamidine

Produkt 1

HCID 86663308N'-(acetyloxy)-4-iodobenzenecarboximidamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 7914Diisopropyl EtherLösungsmittel

Versuchsvorschrift

To a suspension of the product obtained in Step A above (8.43 g, 32.17 mmol) in 200 ml of CH2Cl2 there are added 6.72 ml (48.2 mmol) of triethylamine. 3.34 ml (35.4 mmol) of acetic anhydride are added dropwise and the solution is stirred overnight at ambient temperature. After washing 3 times with water and then with brine, the organic phase is dried over MgSO4 and evaporated. The solid obtained is taken up in isopropyl ether and then filtered to yield the title product.

Aufarbeitung

  1. washAfter washing 3 times with water
  2. dry with materialwith brine, the organic phase is dried over MgSO4
  3. customevaporated
  4. customThe solid obtained
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-8dc8ac9c5a664b2bb408d871c4126b8e
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569285B2

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