Toluene → (1S)-4-Methylcyclohex-3-ene-1-carbonyl chloride

HRID 1046458Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1046458
[CH3:1][C:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=O)[CH2:4][CH:3]=1.C1(C)C=CC=CC=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[CH3:1][C:2]1[CH2:7][CH2:6][C@H:5]([C:8]([Cl:21])=[O:10])[CH2:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 1140TolueneHCID 65578Oxalyl chlorideHCID 10877190(1S)-4-methylcyclohex-3-ene-1-carboxylic acid

Produkt 1

HCID 12951476(1S)-4-Methylcyclohex-3-ene-1-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

(1S)-4-Methyl-cyclohex-3-ene-1-carboxylic acid (250 mg, 1.78 mmol), azeotropically dried by evaporation from toluene was dissolved in dichloromethane (4 mL) and treated with dimethylformamide (1 drop). The reaction mixture was cooled to 0° C. and treated dropwise with oxalyl chloride (0.42 mL, 4.5 mmol). The reaction mixture was allowed to warm to ambient temperature while stirring for 4 h. The solution was concentrated, treated with hexanes and concentrated again to afford (1S)-4-methyl-cyclohex-3-ene-1-carboxylic acid chloride as a light yellow oil which was used immediately in the next step.

Aufarbeitung

  1. temperatureto warm to ambient temperature
  2. concentrationThe solution was concentrated
  3. additiontreated with hexanes
  4. concentrationconcentrated again

Quellen und Nachweise

ORD-Eintrag
ord-256b9ca85b724328bc5042cf4249a0e8
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569302B2

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